O presente estudo realiza uma análise da aplicação do artigo 26-A da LDB (Brasil, 1996), que determina a obrigatoriedade do ensino de história e cultura africana, afrobrasileira e indígena nas instituições de ensino. A pesquisa tem por objetivo compreender de que forma gestores escolares implementam a educação das relações étnico-raciais (ERER) em escolas de dois municípios do Vale do Rio Caí/RS. Em termos metodológicos, configura-se como estudo de caso, de cunho quali-quantitativo, com produção de dados por meio de questionários semi-estruturados (...) encaminhados aos gestores das escolas da rede pública de Bom Princípio e São Sebastião do Caí, situados no Rio Grande do Sul/Brasil. Os resultados apontam desconfortos e incertezas quanto à condução de situações de racismo existentes nas escolas, bem como, sinalizam a necessidade de suporte pedagógico e de espaços de reflexão coletiva sobre o tema de forma que possibilitem a reeducação das relações étnico-raciais. (shrink)

Evolutionary theory is formulated in terms of individuals that carry heritable information and are subject to selective pressures. However, individuality itself is a trait that had to evolve - an individual is not an indivisible entity, but a result of evolutionary processes that necessarily begin at the lower level of hierarchical organisation. Traditional approaches to biological individuality focus on cooperation and relatedness within a group, division of labour, policing mechanisms and strong selection at the higher level. Nevertheless, despite considerable theoretical (...) progress in these areas, a full dynamical first-principles account of how new types of individuals arise is missing. To the extent that individuality is an emergent trait, the problem can be approached by recognising the importance of individuating mechanisms that are present from the very beginning of the transition, when only lower-level selection is acting. Here we review some of the most influential theoretical work on the role of individuating mechanisms in these transitions, and demonstrate how a lower-level, bottom-up evolutionary framework can be used to understand biological complexity involved in the origin of cellular life, early eukaryotic evolution, sexual life cycles and multicellular development. Some of these mechanisms inevitably stem from environmental constraints, population structure and ancestral life cycles. Others are unique to specific transitions - features of the natural history and biochemistry that are co-opted into conflict mediation. Identifying mechanisms of individuation that provide a coarse-grained description of the system's evolutionary dynamics is an important step towards understanding how biological complexity and hierarchical organisation evolves. In this way, individuality can be reconceptualised as an approximate model that with varying degrees of precision applies to a wide range of biological systems. (shrink)

Comparative study of the Yoga of Patañjali and Jaina Yoga.

Straipsnyje aptariami pagrindinių fizinio ugdymo koncepcijų filosofiniai aspektai pabrėžiant filosofijos kaip temiškai neredukuoto mokslo tarpdalykinę reikšmę. Fizinio ugdymo tikslų ir metodų konceptualizavimas neišvengiamai suponuoja vienokią ar kitokią kūno sampratą. Straipsnio autoriai remiasi principine nuostata, kad filosofinei refleksijai sportas ir fizinis aktyvumas atsiskleidžia kaip tam tikros žmogaus saviaktualizacijos formos. Straipsnyje atskleidžiama fizinio ugdymo koncepcijų kaitos sąsaja su filosofinio požiūrio į kūną pokyčiais, išryškinami holistinio požiūrio į individą ir jo ugdymą formavimosi esminiai etapai.

Besides Giving An Account Of The Origin And Development Of Buddhism As Well As The Works Of Vasubandhu And Reviewing The Abhidarwa Literature Of Buddhism, Written In Sanskrit And Pali This Book Thoroughly Analyses The Doctrine Of Sarvastivada And The Buddhist Conceptions Of Feeling, Perception, Consciousness And Impression.

Several modern commentators of Dignaga have puzzled over the 5th century Buddhist philosopher1s theory of the triple condition of the inferential sign. Th. Stcherbatsky (1932), Richard Hayes (1988) and Bimal K. Matilal (1986) have wondered at the reasons for Dignaga’s insistence on the inclusion of the secondcondition, which seems to be the logical equivalent of the third condition. Do the three criteria together furnish patterns of valid inference which differ from those patterns furnished by criteria one and three alone? In (...) this paper, I detail three types of cases which underline the importance of the inclusion of the second criterion. (shrink)

En esta investigación se analizará y fundamentará el concepto de pensamiento crítico, entendido como un importante objetivo educativo, en relación con el concepto de verdad. En primera instancia se revisará el concepto de pensamiento crítico encontrado en el currículo nacional como ejemplo. Luego se analizará y fundamentará epistemológicamente el pensamiento crítico desde sus componentes epistémicos, desde los aportes del filósofo educativo Harvey Siegel y la epistemología confiabilista de Alvin Goldman. Desde esta fundamentación se vinculará el pensamiento crítico con el concepto (...) de verdad al entenderlo como un proceso conducente a la verdad. Esto permitirá tener una base diferente para conceptualizar el pensamiento crítico como objetivo educativo, reformular este concepto en los documentos ministeriales y derivar sugerencias docentes por medio de las cuales formar en los estudiantes el pensamiento crítico. Lo anterior lleva a reconsiderar la verdad como un objetivo epistémico primario en la educación por derecho propio, junto al desarrollo del pensamiento crítico. (shrink)

Abstract“Selfish” gene theories have offered invaluable insight into eukaryotic genome evolution, but they can also be misleading. The “selfish mitochondrion” hypothesis, developed in the 90s explained uniparental organelle inheritance as a mechanism of conflict resolution, improving cooperation between genetically distinct compartments of the cell. But modern population genetic models provided a more general explanation for uniparental inheritance based on mutational variance redistribution, modulating the efficiency of both purifying and adaptive selection. Nevertheless, as reviewed here, “selfish” conflict theories still dominate the (...) literature. While these hypotheses are rich in metaphor and highly intuitive, selective focus on only one type of mitochondrial mutation limits the generality of our understanding and hinders progress in mito‐nuclear evolution theory. Recognizing that uniparental inheritance may have evolved—and is maintained across the eukaryotic tree of life—because of its influence on mutational variance and improved selection will only increase the generality of our evolutionary reasoning, retaining “selfish” conflict explanations as a special case of a much broader theory. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

Floridi’s work, although diverse and multifaceted, portrays a solid coherence across his different lines of work. Among his wealth of interests and results, we highlight his recent work on information logics, on the ethics of information technology, and his rigorous (and vigorous) philosophical analysis of recent technological trends and developments in information technology. In the present article we illustrate, by means of some connecting arguments, the diversity and coherence of Floridi’s work. We also show how his work, although fundamentally philosophical (...) in nature, can be used to build solid foundations for scientific and entrepreneurial endeavours of higher quality. More specifically, we discuss how the combination of results from the three lines of work referred to above can be used as ground for the organisation of higher quality programmes to augment the capabilities and effectiveness of governmental systems through information and communications technology, a trend that has been explored in many nations and that has been coined Electronic Government. Electronic Government programmes that improve the capabilities of citizens to interact with each other and with governments, as well as the capabilities of governments to listen to the needs and aspirations of citizens, have the potential to contribute to the construction of more democratic states. Electronic Government systems that rely on ready made models to prescribe to citizens how best they should interact with each other and with the public administration are, however, by construction non-democratic. Hence, it can be a moral and ethical matter for governments to choose which line of technological development they take. (shrink)

The Theragatha of the Khuddakanikaya has only ten stanzas uttered by the Elder Kaludayi. However, the Madhuratthavilasini, the commentary to the Buddhavamsa preserves 64 stanzas ascribed to the Elder while the Visuddhajanavilasini, the commentary to the Apad?na quotes a different series consisting of 48 stanzas ascribed to him. It is probable that these two series contain ancient verses which could not be accommodated within the Pali canon and then continued to be preserved in the commentaries as extra-canonical texts. Yet some (...) of the verses in these two series appear to be later compositions. The present article offers a literal translation of the Bv-a and the Ap-a verses, which have so far received no scholarly attention. (shrink)

Socialinio darbo teoretikai sutinka, kad Pierre’o Bourdieu sociologijos įtaka sociali­ niam darbui plečiasi ir gilėja. Kita vertus, kai kalbama apie socialinio darbo profesiją, tie patys teoretikai ignoruoja P. Bourdieu nuostatą nuo profesijos tyrimų pereiti prie profesinio lauko analizės. P. Bourdieu profesijos fenomeną laikė biurokratinės pri­ gimties konceptualizacija, kuri įtvirtina mokslinio mąstymo logikai prieštaraujančias heteronomijos apraiškas. Straipsnyje siekiama įgyvendinti P. Bourdieu reikalavimą ir, pritaikius jį socialiniam darbui, nuo socialinio darbo profesijos analizės pereiti prie socialinio darbo profesinio lauko tyrimų. Straipsnyje ieškome atsakymo (...) į klausimą, kaip keičiasi su socialiniu darbu siejamų veiklos formų arba praktikų traktavimas, kai socialinio darbo profesijos analizę keičia socialinio darbo lauko tyrimas. Palyginę trijų skirtingų šalių – JAV, Japonijos ir Lietuvos – socialinio darbo profesinės veiklos lau­ kus, priėjome prie išvados, kad profesinio lauko, kitaip nei profesijos, požiūris sudaro prielaidas įtraukti į socialinio darbo lauką tas socialinio įgalinimo praktikas, kurios, socialinio darbo profesijos požiūriu, lieka anapus biurokratinio socialinio darbo reg­ lamento. (shrink)

El autor toma las ideas fundamentales que los liberales han legado al mundo contemporáneo: la libertad y la propiedad fueron sus valores predilectos y su vigencia permanece hasta la actualidad. Empeñados en construir un Estado proclive a la libertad y la propiedad, los liberales idearon la soberanía, la separación de poderes y la posibilidad de que alguna vez hubiera Estados regidos por Constituciones. Hoy esas ideas constituyen los pilares de nuestra organización política.

La composición de planes de estudio comprometidos con una educación “pequeña” y todo lo que escapa a la tradición científica, nos ayuda a _‘sentirpensar’_ el dolor e ir más allá, en busca de una vida bella. Las rutinas escolares revelan el pulso de la vida en innumerables redes educativas, a través de experimentos artísticos en la formación y procesos culturales _‘dentrofuera’ _de las escuelas y universidades, creando_ 'conocimientossignificados'._.

H. G. Gadamer’s “philosophical hermeneutics” elicited a controversial response in contemporary philosophy. R. Rorty and G. Vattimo tried to impart a more relativistic shade to H. G. Gadamer’s hermeneutics. In contrast, J. Derrida was inclined to consider H. G. Gadamer hermeneutics more dependent on the previous epoch of “metaphysics of presence”. This article purposes to reveal the points of contact and division between the thinking strategies employed by hermeneutics and deconstruction, providing theoretical arguments why H. G. Gadamer hermeneutics should not (...) be reduced to the so-called “metaphysics of presence”. The question whether H. G. Gadamer’s hermeneutics belongs to “metaphysics of presence” or not is closely intertwined with the problem of dogmatism of meaning and relativism of meaning. J. Derrida was inclined to regard H. G. Gadamer’s hermeneutic as a theory of a search for and discovery of a pre-existing or objective meaning which accounts for the theory’s persistent belonging with metaphysical dogmatism. In opposition to such judgement, this article seeks to substantiate the following thesis: in H. G. Gadamer’s hermeneutics which is based on the “good will” to understand, the problem of dogmatism of meaning (there is one universal objective meaning or truth) and relativism of meaning (there is a multitude of meanings open to interpretation without reference to the primary signified) can be solved by taking into consideration the way offered by E. Husserl phenomenology, i.e. by understanding any possible “thing” (die Sache) as a “thing-in-itself” only in different perceptual perspectives (die perspektivischen Abschattungen). (shrink)

This paper presents a detailed analysis of a previous work that described the dynamic behavior of an antique stamp mill. The stamp mill application was for breaking ore stones as part of silver production. The dynamic analysis was established from a modern description of the kinematic chain. Since there is no technical data or archeological reports, the model was reconstructed using the dimensions described in original documents and assuming the operation conditions from different technical references. The model was validated using (...) the typical production rates from the pre-industrial revolution period (XVI to XVIII centuries). The results show a proper method for reconstructing the engineering data of antique mechanisms and provide the basis for reproducing these types of mechanisms with modern engineering concepts. The data can be extrapolated to other similar mills that were developed based on this functional principle. (shrink)

Energía: vital y fatal. Vital pues cierta cantidad de energía se ha convertido en un aspecto indispensable para las sociedades y personas modernas. Fatal pues los sistemas energéticos han generado la mayor parte de las emisiones de gases efecto invernadero desde por lo menos la segunda mitad del siglo veinte. Por lo tanto, es indispensable analizar las cuestiones de energía desde el punto de vista de su uso buscando responder preguntas como ¿cuánta energía se requiere para mantener o mejorar niveles (...) de bienestar humano?, ¿qué países han logrado alcanzar niveles altos de bienestar con niveles relativamente bajos de uso de la energía y cómo lo han logrado?, ¿qué impacto tiene nuestra comprensión del bienestar humano en cómo reflexionamos sobre la relación entre energía y bienestar? Este artículo tiene como objetivo presentar la historia del estudio de las relaciones energía-bienestar imperativa en la lucha por mitigar el cambio climático, desde una perspectiva de límites medioambientales. (shrink)

This study analyzes the most important predictors of acceptance of social network sites in a sample of Chilean elder people. We employ a novelty procedure to explore this phenomenon. This procedure performs apriori segmentation based on gender and generation. It then applies the deep learning technique to identify the predictors by segments. The predictor variables were taken from the literature on the use of social network sites, and an empirical study was carried out by quota sampling with a sample size (...) of 395 older people. The results show different predictors of social network sites considering all the samples, baby boomer males and females, silent males and females. The high heterogeneity among older people is confirmed; this means that dealing with older adults as a uniform set of users of social network sites is a mistake. This study demonstrates that the four segments behave differently, and many diverse variables influence the acceptance of social network sites. (shrink)

Las expectativas de reconocimiento que tienen los migrantes puede entenderse en desde la noción de falso reconocimiento, en que el sujeto se identifica con la posición desfavorable que le impone la sociedad receptora. Las expectativas de los migrantes están mediadas por la percepción de que se contrae una deuda con la sociedad en virtud de que esta le ha entregado un espacio de oportunidades para la realización de un proyecto de vida orientado al bienestar y la seguridad. Lo cual redunda (...) en una concepción del acceso a los derechos restringida y centrada en el acceso al mercado de trabajo y de bienes de consumo. En este marco las principales estrategias de incorporación identificadas son el ocultamiento, la adaptación, la distinción al interior de los colectivos, el fortalecimiento de las redes y la priorización del trabajo. (shrink)

El último año un número significativo de países desarrollados y del tercer mundo iniciaron procesos de transformación social y política a partir de levantamientos, revoluciones y movimientos impulsados por una ciudadanía hasta ahora distanciada e incluso segregada de la esfera política. En algunos países el imperio del mercado, en otros la fuerza represiva de regímenes autoritarios, en los más privilegiados, un nihilismo extendido producto del bienestar material acumulado, venía desde hace añ..

El autor realiza un contrapunto entre un texto basado en supuestos científicos -"Del bosque a la ciudad: ¿Progreso?", de Juan Pablo Orrego- que realiza un diagnóstico y una prospección del sistema biótico, en particular del bosque, y que llama a la responsabilidad y a a una acción ante la lógica depredadora capitalista, además de criticar una visión occidental antropocentrista; y el texto, Sobre árboles y madres, del filósofo chileno Patricio Marchant, de interpretación filosófica y de reivindicación poética, que resalta la (...) quema como pérdida insoslayable del fundamento originario en la pérdida originaria del fundamento. No presenta el autor una tercera parte conclusiva, dejándolo esto como un surgimiento de las dos lecturas. (shrink)

Humans have been using fire for hundreds of millennia, creating an ancestral expansion toward the nocturnal niche. The new adaptive challenges faced at night were recurrent enough to amplify existing psychological variation in our species. Night-time is dangerous and mysterious, so it selects for individuals with higher tendencies for paranoia, risk-taking, and sociability. During night-time, individuals are generally tired and show decreased self-control and increased impulsive behaviors. The lower visibility during night-time favors the partial concealment of identity and opens more (...) opportunities for disinhibition of self-interested behaviors. Indeed, individuals with an evening-oriented chronotype are more paranoid, risk-taking, extraverted, impulsive, promiscuous, and have higher antisocial personality traits. However, under some circumstances, such as respiratory pandemics, the psychobehavioral traits favored by the nocturnal niche might be counter-productive, increasing contagion rates of a disease that can evade the behavioral immune system because its disease cues are often nonexistent or mild. The eveningness epidemiological liability hypothesis presented here suggests that during the COVID-19 pandemic, the evening-oriented psychobehavioral profile can have collectively harmful consequences: there is a clash of core tendencies between the nocturnal chronotype and the recent viral transmission-mitigating safety guidelines and rules. The pandemic safety protocols disrupt much normal social activity, particularly at night when making new social contacts is desired. The SARS-CoV-2 virus is contagious even in presymptomatic and asymptomatic individuals, which enables it to mostly evade our evolved contagious disease avoidance mechanisms. A growing body of research has indirectly shown that individual traits interfering with social distancing and anti-contagion measures are related to those of the nocturnal chronotype. Indeed, some of the social contexts that have been identified as superspreading events occur at night, such as in restaurants, bars, and nightclubs. Furthermore, nocturnal environmental conditions favor the survival of the SARS-CoV-2 virus much longer than daytime conditions. We compare the eveningness epidemiological liability hypothesis with other factors related to non-compliance with pandemic safety protocols, namely sex, age, and life history. Although there is not yet a direct link between the nocturnal chronotype and non-compliance with pandemic safety protocols, security measures and future empirical research should take this crucial evolutionary mismatch and adaptive metaproblem into account, and focus on how to avoid nocturnal individuals becoming superspreaders, offering secure alternatives for nocturnal social activities. (shrink)

In the Tractatus Logico-Philosophicus the identity signal is excluded from any meaningful language use, because expressions such as “a = a” and “a = b” cannot be elementary and necessary propositions at the same time. Hence, the identity is used as a operation. That use does not intended to be be meaningful, but only to indicate the intersubstitutable nature of the signs involved.